APUDOMA: WHAT IS APUDOMA?
Definition: What is "Apudoma"?
An apudoma is any endocrine tumor that arises from an APUD cell (APUD, meaning amine precursor uptake & decarboxylation) properties. These cells, which are derived from neural crest cells, are from structures such as the prostate, pancreas & ampulla of Vater. First identified in 1975, Apudoma is a very general term. As such, most doctors & scientists prefer to use a more specific term when possible, such as apudoma of gall bladder.
"Structurally, apudoma tumors often display electron-dense granules, which produce multiple regulatory amines & hormones, chromogranin A or C, synaptophysine & neuron-specific enolase. Amine precursor uptake & decarboxylation cells are known to give rise to islet cell tumors of the pancreas, medullary carcinomas of the thyroid, phaeochromocytomas, melanomas & carcinoid tumors. As such, symptoms & histology of pancreatic islet cell tumors & apudoma have striking similarities. "