AASE SMITH SYNDROME (OR AASE SYNDROME) & TREATMENT
Definition: What is "Aase Smith syndrome (or Aase syndrome)"?
Aase smith syndrome (or aase syndrome) definition: Aase Smith syndrome also known as Aase syndrome is a very rare disorder that can be inherited. It is often characterized by skeletal & joint defects. Aase syndrome is known as an autosomal dominant condition. The genetic origin of the illness is still not known. Anemia which results from this syndrome is often caused by the underdevelopment of bone marrows. These bone marrows are where formation of blood cells takes place. The syndrome was named after two pediatricians who were David Weyhe Smith & Jon Morton Aase.
Symptoms & Signs
Some of the most common traits that can be found are: mild retardation on a person's growth; a skin that appears pale; a setback on the closure of the soft spots or fontanelles; thin shoulders; thumbs that appear to have three joints; little knuckles; very little finger joint creases; inborn contractures; cleft palate; ears that are deformed; & eyelids that droop.
Treatment: How to Treat "Aase Smith syndrome (or Aase syndrome)"?
For patients with complications on anemia, it is advisable that frequent transfusion of blood be done (especially on the primary year of life). Prednisone can be administered but this should be evaded during infancy as this medicine can badly affect the development of brain & also the child's growth. If all other treatment fails, then a bone marrow transplant is necessary.
Just like most diseases that are genetic in origin, there is no way to prevent this condition. The complications could be limited if all of the infections are properly treated (especially in the case of low counts of white blood cells).
A complete blood count or CBC will manifest a case of anemia where the white blood cells have noticeably low number. Another test is the echocardiogram which may show defects of the heart (the most common defect appears to be the failing of ventricle in the septum). The patient could also undergo x-ray tests to show any abnormalities on his skeletal system. A biopsy for the bone marrows may also be done.
It is believed that anemia is resolved as the patient ages. This is possible as long as the symptoms have been managed.
Oxygenation of the blood can be decreased due to this syndrome & this could also result to fatigue & much weakness. Complications of the heart could result from a single defect especially when treatment has not been given immediately. The most dismal cases involve early death or still birth.